Sedating newborns

Uses: Daytime sedation; preoperative sedation Oral: -Recommended dose: 100 to 200 mg orally once a day -Maximum dose: 400 mg during a 24-hour period Parenteral: -Recommended dose: 100 to 320 mg IM or IV once a day -Maximum dose: 400 mg during a 24-hour period Comments: -This drug may begin to lose effectiveness for inducing and maintaining sleep after 2 weeks.

-Hematopoietic, renal and hepatic function periodically, especially during long-term therapy.Procedural sedation may be defined as the administration of sedative or dissociative agents, with or without analgesics, to induce a state that allows the patient to tolerate unpleasant procedures while maintaining cardiorespiratory function.Specifically, the drugs, doses, and techniques used are not likely to produce a loss of protective airway reflexes.However, with this small number of newborns studied, the safety can not be proven. (1980 to September 30, 2010) and the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library 2010, Issue 2) for eligible studies without language restriction.We searched reference lists of identified articles and abstracts submitted to Pediatric Academic Societies (2002 to 2009), and international trials registries for eligible articles.

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